Therapeutic Areas and Products
Fibrinogen deficiency: Caused by an absence/low levels of fibrinogen or dysfunctional fibrinogen.
May lead to bleeding or clotting events
Fibrinogen deficiency can be inherited (congenital) or acquired.
Two types of congenital fibrinogen deficiency:
- Type I deficiencies (quantitative abnormalities): Afibrinogenemia or Hypofibrinogenemia
- Type II deficiencies (qualitative abnormalities): Dysfibrinogenemia
Congenital fibrinogen deficiencies affect males and females equally.
Bleeding manifestations in afibrinogenemia can range from mild to severe and can include:
- Oral bleeding
- Joint and muscle bleeding
- Gastrointestinal bleeding
- Heavy menstrual bleeding
- Traumatic and surgical bleeding
In hypofibrinogenemia, bleeding episodes are usually mild; bleeding generally occurs following trauma or surgery.
1. Asselta R, Duga S, Tenchini M. Molecular basis of quantitative fibrinogen disorders. J Thromb Haemost. 2006;4(10):2115-2129. 2. Figure source: https://ib.bioninja.com.au/standard-level/topic-6-human-physiology/63-defence-against-infectio/clotting.html 3. Peyvandi F, Haertel S, Knaub S, Mannucci PM. Incidence of bleeding symptoms in 100 patients with inherited afibrinogenemia or hypfibrinogenemia. J Thromb Haemost. 2006;4(7):1634-1637. 4. Bevan et al. Fibrinogen replacement therapy. Thromb Res. 2009;124 Suppl 2:S12-516.