Factor XIII Deficiency

Have a Question? Use Our New Chat Feature! Chat with our Medical Information Specialists by clicking on the Chat with us button, now available in the lower right corner of this screen.

Hematology

35+ Years Treating Hemophilia

CSL Behring has over 35 years of experience in the field of hematology. From disorders that span the coagulation cascade to the management of urgent reversal of acquired bleeding, CSL Behring continues to invest in this area and remains committed to continuing our innovations in this field.

Disease States	Educational Materials	Key Publications	CSL Hematology Products	Pipeline

Factor XIII Deficiency

Congenital factor XIII deficiency is an autosomal recessive disorder.

Acquired factor XIII deficiency can be seen in the setting of cardiac surgery, malignancy, infection and irritable bowel disease.

Caused by mutations in the genes that code for either FVIII subunit A or B (rarer).

Most common bleeding sites include umbilical stump, soft tissue, surgical and intracranial.

Poor wound healing is often present.

Measure FXIII activity.

PT, aPTT, and thrombin time are usually normal.
Genetic analysis to identify gene mutation.

Prophylaxis recommended especially with levels <10%