Alpha-1 Antitrypsin Deficiency (Alpha-1) is a genetic (inherited) condition – it is passed from parents to their children through their genes. Alpha-1 may result in serious lung disease in adults and/or liver disease at any age. Earlier screening helps to accurately diagnose Alpha-1, allowing for a treatment plan to be established.

Alpha-1 antitrypsin (A₁AT) is a protein produced primarily by hepatocytes and released into circulation by the liver. A₁AT functions in the lungs to inactivate neutrophil elastase, a powerful protease that contributes to the innate immune response.

A₁AT keeps neutrophil elastase levels in check, thereby protecting the lung against alveolar wall destruction. A₁AT provides > 90% of the anti-neutrophil elastase protection in the lungs.