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Alpha-1 Antitrypsin Deficiency

Alpha-1 Antitrypsin Deficiency (AATD or Alpha-1) is a genetic (inherited) condition – it is passed from parents to their children through their genes. Alpha-1 may result in serious lung disease in adults and/or liver disease at any age. Earlier screening helps to accurately diagnose Alpha-1, allowing for a treatment plan to be established.

Alpha-1 antitrypsin (A1AT) is a protein produced primarily by hepatocytes and released into circulation by the liver. A1AT functions in the lungs to inactivate neutrophil elastase, a powerful protease that contributes to the innate immune response.

A1AT keeps neutrophil elastase levels in check, thereby protecting the lung against alveolar wall destruction. A1AT provides > 90% of the anti-neutrophil elastase protection in the lungs.

CSL Alpha-1 Products

For U.S. Healthcare Professionals only
For U.S. Healthcare Professionals only

The purpose of this CSL Behring Medical Affairs website is to support Healthcare Professionals with scientific information. This website is also a channel for U.S. Healthcare Professionals to submit questions or connect with CSL Behring U.S. Healthcare Professionals. The information provided is for educational purposes only and is not intended to promote any products. By continuing to use this site you are acknowledging that you are a US Healthcare Professional

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