Hemophilia A
- One International Unit (IU) of factor VIII (FVIII) activity per kg body weight increases the circulating FVIII level by approximately 2.0 IU/dL. Individualize dosage based on the patient’s weight, type and severity of hemorrhage, FVIII level, and presence of inhibitors (2.1).
VWD
- Treatment of bleeding episodes – 40-80 IU VWF:Ristocetin Cofactor (RCo) per kg body weight (BW) every 8-12 hours.
- Prevention of excessive bleeding during and after surgery for all types of VWD
Type of Surgery
(see Full Prescribing Information
for monitoring recommendations) |
Calculation of Loading Dose
Initial maintenance dose should be half the loading dose
(see Full Prescribing Information for monitoring recommendations) |
| Major Surgery (2,3) |
Δ * VWF:RCo x BW (kg) = IU VWF:RCo required
IVR†
|
| Minor/Oral Surgery‡ (2,3) |
Δ * VWF:RCo x BW (kg) = IU VWF:RCo required
IVR |
| Emergency Surgery (2,3) |
Administer a dose of 50-60 IU VWF:RCo/kg BW |
* Δ = Target peak plasma VWF:RCo level - baseline plasma VWF:RCo level.
† IVR = in vivo recovery as measured in the patient. If the IVR is unknown, use 2.0 IU/dL per IU/kg
‡ Oral surgery is defined as extraction of fewer than three teeth, if the teeth are non-molars and have no bony involvement
)
