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vials of medicine with silver caps)


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Product Information

CORIFACT is a Factor XIII concentrate indicated for adult and pediatric patients with congenital Factor XIII deficiency for:
  • Routine prophylactic treatment
  • Peri-operative management of surgical bleeding

Do not use in patients with known anaphylactic or severe systemic reactions to human plasma-derived products.

  • 40 International Units (IU) per kg body weight.
  • Adjust dose ±5 IU per kg to maintain 5% to 20% trough level of FXIII activity.
  • For routine prophylaxis, administer every 28 days
FXIII Activity Trough Level (%) Dosage Change
One trough level of <5% Increase by 5 IU per kg
Trough level of 5% to 20% No Change
Two trough levels of >20%  Decrease by 5 IU per kg
One trough level of >25% Decrease by 5 IU per kg
  • For peri-operative management of surgical bleeding, individualize dose based on the patient’s FXIII activity level, type of surgery, and clinical response
  • Following are dose adjustment examples for peri-operative management in reference to the patient’s last prophylactic dose
Time Since Last Dose Dose
Within 7 days Additional dose may not be needed
8 - 21 days Additional partial or full dose may be needed based on FXIII activity level
21 - 28 days Full prophylactic dose
  • For intravenous use only
  • Administer at a rate not exceeding 4 mL per minute
  • Each vial contains 1000-1600 units of lyophilized powder for reconstitution. The actual FXIII potency for each lot is printed on the vial label and carton.
  • The potency expressed in International Units is determined using the Berichrom activity assay, referenced to the current International Standard for Blood Coagulation Factor XIII, Plasma
For U.S. Healthcare Professionals only
For U.S. Healthcare Professionals only

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