Thromboembolism after treatment with 4 factor prothrombin complex concentrate or plasma for warfarin related bleeding

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Go et al. 2022
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INR and vitamin K–dependent factor levels after vitamin K antagonist reversal with 4F-PCC or plasma

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Hood et al. 2022
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Thromboembolic Events After Vitamin K Antagonist Reversal With 4-Factor Prothrombin Complex Concentrate: Exploratory Analyses of Two Randomized, Plasma-Controlled Studies
Milling TJ Jr, et al., Ann Emerg Med 2016
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Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomized trial

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Goldstein JN, et al., Lancet 2015
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Increased risk of volume overload with plasma compared with four-factor prothrombin complex concentrate for urgent vitamin K antagonist reversal
Refaai, MA, et al., Transfusion 2015
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Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: A randomized, plasma-controlled, phase IIIb study

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Sarode R, et al., Circulation 2013
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Impact of infusion speed on the safety and effectiveness of prothrombin complex concentrate. A prospective clinical trial of emergency anticoagulation reversal
Pabinger I, et al., Ann Hematol 2010
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Prothrombin complex concentrate (Beriplex P/N) for emergency anticoagulation reversal: a prospective multinational clinical trial
Pabinger I, et al., Thromb Haemost 2008
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Pharmacokinetics of BERIPLEX P/N prothrombin complex concentrate in healthy volunteers
Ostermann H, et al., Thromb Haemost 2007
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Efficacy and safety of a prothrombin complex concentrate with two virus-inactivation steps in patients with severe liver damage
Lorenz R, et al., Eur J Gastroenterol Hepatol 2003
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